6/28/2023 0 Comments Mediocre author ijeoma![]() ![]() elegans neurons and their connections have been mapped out and its cells are accessible for genetic manipulation. elegans has only 302 neurons (rather than billions) and only six serotonin receptors (rather than the 14 found in people). elegans, but to a more manageably limited degree. ![]() These same complexities that scientists face in people are all afoot in the nematode worm C. ![]() ![]() There are many different types of serotonergic neurons with widespread projections throughout the brain and serotonin acts through many different receptors, which are often activated in concert to change the way that neural circuits work.” “There have been major challenges in rationally developing psychiatric drugs that target the serotonergic system,” says Steve Flavell, associate professor in the Picower Institute and MIT’s Department of Brain and Cognitive Sciences, and senior author of the study in Cell. In a new study, researchers at The Picower Institute for Learning and Memory at MIT working in a simple animal model present a comprehensive accounting of how serotonin affects behavior from the scale of individual molecules all the way to the animal’s whole brain. To improve those drugs and to invent better ones, scientists need to know much more about how the molecule affects brain cells and circuits both in health and amid disease. Because serotonin is one of the primary chemicals the brain uses to influence mood and behavior, it is also the most common target of psychiatric drugs. ![]()
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